Journal article
Fully replicable and automated retention measurement setup for characterization of bio-adhesion
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark1
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark2
Department of Health Technology, Technical University of Denmark3
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark4
Technical University of Denmark5
Manufacturing Engineering, Department of Mechanical Engineering, Technical University of Denmark6
Department of Mechanical Engineering, Technical University of Denmark7
The retention model by Rao and Buri is often used to characterize microparticles and other drug delivery systems for their bio-adhesive properties. Currently, these experiments are performed on customized setups, reducing reproducibility of results obtained in different labs. As a solution, we propose a fully replicable retention model, which can be constructed by parts mostly made by 3D printing and laser cutting as well as a limited amount of other easy to source and commercially available parts.
In addition of being fully replicable, the setup features integration of a climate-controlled chamber, a peristaltic pump and an autosampler, thereby enabling fully automated but customized control of the experiments. Using the presented retention model setup and an automated experimental sequence, the setup has been proven capable of investigating mucoadhesion of differently shaped particles to porcine intestinal tissue.
Language: | English |
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Publisher: | Elsevier |
Year: | 2019 |
Pages: | e00071 |
ISSN: | 24680672 |
Types: | Journal article |
DOI: | 10.1016/j.ohx.2019.e00071 |
ORCIDs: | Tosello, Guido and Boisen, Anja |
Bioadhesion Ex vivo flow model Flow-through method Mucoadhesion Open labware Open source hardware Retention model