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Journal article

Hesseltins B–G, novel meroterpenoids from a new Penicillium species

By Phipps, Richard Kerry1,2; Gotfredsen, Charlotte Held3,4; Paludan, Søren R.5; Frisvad, Jens Christian1,2; Eriksen, Kathrine6; Petersen, Bent O.7; Duus, Jens Øllgaard7; Larsen, Thomas Ostenfeld1,2

From

Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark1

Department of Systems Biology, Technical University of Denmark2

Organic Chemistry, Department of Chemistry, Technical University of Denmark3

Department of Chemistry, Technical University of Denmark4

Department of Medicinal Microbiology and Immunology5

Technical University of Denmark6

Carlsberg Research Center7

Six new meroterpenoid compounds, hesseltins B–G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A.

None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay.

Language: English
Year: 2011
Pages: 598-601
ISSN: 18733581 and 00404039
Types: Journal article
DOI: 10.1016/j.tetlet.2010.11.140
ORCIDs: Gotfredsen, Charlotte Held , Frisvad, Jens Christian and Larsen, Thomas Ostenfeld
Keywords

Antiviral Hesseltin Meroterpenoid Penicillium Photoisomerism

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