Journal article
Additive Manufacturing of Microreservoir Devices for Oral Drug Delivery Using an Acculas BA-30 Micro-Stereolithography Instrument: A Feasibility Study
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark1
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark2
Department of Health Technology, Technical University of Denmark3
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark4
Manufacturing Engineering, Department of Mechanical Engineering, Technical University of Denmark5
Department of Mechanical Engineering, Technical University of Denmark6
Yamagata University7
Within the research and the development of protective carrier platforms intended for oral drug delivery, polymeric microreservoir devices with sizes around 300μm have been proposed as a delivery system capable of unidirectional drug release. So far, microreservoir devices have been fabricated with simple shapes by means of high-throughput fabrication methods.
In this feasibility study, stateof-the-art micro-stereolithography 3D printing is used for the fabrication of various microreservoir geometries. Scanning electron microscopy characterization and conducted resolution tests demonstrated the capability of the used technology and unveils challenges and opportunities associated with the proposed fabrication process.
Language: | English |
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Publisher: | The Electrochemical Society |
Year: | 2019 |
Pages: | B3257-B3263 |
ISSN: | 19457111 and 00134651 |
Types: | Journal article |
DOI: | 10.1149/2.0421909jes |
ORCIDs: | Jensen, Kristian E. , Tosello, Guido , Boisen, Anja , 0000-0002-8857-4943 and 0000-0002-2803-8532 |