Journal article
Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites
Korea Advanced Institute of Science and Technology1
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
New Bioactive Compounds, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Network Reconstruction in Silico Biology, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale.
Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism.
Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.
Language: | English |
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Year: | 2014 |
Pages: | 255-268 |
ISSN: | 18731899 and 07349750 |
Types: | Journal article |
DOI: | 10.1016/j.biotechadv.2013.10.008 |
ORCIDs: | 0000-0003-0599-3091 , Charusanti, Pep and Palsson, Bernhard |
Constraint-based flux analysis Databases Knowledgebases Omics techniques Secondary metabolites Streptomyces species Systems biology Systems biotechnology Systems metabolic engineering