Journal article
Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)
Department of Chemical and Biochemical Engineering, Technical University of Denmark1
The Danish Polymer Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
Center for BioProcess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark3
KT Consortium, Department of Chemical and Biochemical Engineering, Technical University of Denmark4
PROSYS - Process and Systems Engineering Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark5
Thiol-ene (TE) based polymer particles have traditionally been prepared via emulsion polymerization in water (using surfactants, stabilizers and co-solvents). Here, we present a green and simple alternative with excellent control over particle size, while avoiding the addition of stabilizers. Glycerol is applied as a dispersing medium for the preparation of offstoichiometric TE (OSTE) microparticles, where sizes in the range of 40 to 400 µm are obtained solely by changing the mixing speed of the emulsions prior to cross-linking.
Control over surface chemistry is achieved by surface functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface.
The application potential of the system is demonstrated by using functional particles as a support for immobilized enzymes in a continuous plug-flow reactor.
Language: | English |
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Publisher: | Wiley |
Year: | 2018 |
Pages: | 1700394 |
ISSN: | 15213927 and 10221336 |
Types: | Journal article |
DOI: | 10.1002/marc.201700394 |
ORCIDs: | Daugaard, Anders Egede , Chiaula, Valeria , Yu, Liyun , Pinelo, Manuel and Woodley, John |