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Journal article

Tackling Cancer with Yeast-Based Technologies

By Ferreira, Raphael1; Limeta, Angelo1; Nielsen, Jens2,3

From

Chalmers University of Technology1

Yeast Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3

The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.

Language: English
Year: 2019
Pages: 592-603
ISSN: 18793096 , 01677799 and 01679430
Types: Journal article
DOI: 10.1016/j.tibtech.2018.11.013
Keywords

CRISPR Cancer vaccines Humanized antibody Immunotherapy Metabolic engineering SDG 3 - Good Health and Well-being SGA

Other keywords

Animals Antineoplastic Agents Bioengineering Biomedical Research Humans Mice Models, Biological Neoplasms Saccharomyces cerevisiae cancer vaccines humanized antibody immunotherapy metabolic engineering

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