Journal article
Synthesis and characterization of ratiometric nanosensors for pH quantification: a mixed micelle approach
Department of Micro- and Nanotechnology, Technical University of Denmark1
Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark2
Amphiphilic Polymers in Biological Sensing, Department of Micro- and Nanotechnology, Technical University of Denmark3
Optical nanoparticle pH sensors designed for ratiometric measurements have previously been synthesized using post-functionalization approaches to introduce sensor molecules and to modify nanoparticle surface chemistry. This strategy often results in low control of the nanoparticle surface chemistry and is prone to batch-to-batch variations, which is undesirable for succeeding sensor calibrations and cellular measurements.
Here we provide a new synthetic approach for preparing nanoparticle pH sensors based on self-organization principles, which in comparison to earlier strategies offers a much higher design flexibility and high control of particle size, morphology and surface chemistry.
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2012 |
Pages: | 4776-4778 |
ISSN: | 1364548x and 13597345 |
Types: | Journal article |
DOI: | 10.1039/c2cc17213e |
ORCIDs: | Almdal, Kristoffer and Andresen, Thomas Lars |