Journal article
CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin
Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ Trm cells on a compartmental and functional basis. In human skin epithelia, CD8+CD49a+ Trm cells produced interferon-γ, whereas CD8+CD49a− Trm cells produced interleukin-17 (IL-17).
In addition, CD8+CD49a+ Trm cells from healthy skin rapidly induced the expression of the effector molecules perforin and granzyme B when stimulated with IL-15, thereby promoting a strong cytotoxic response. In skin from patients with vitiligo, where melanocytes are eradicated locally, CD8+CD49a+ Trm cells that constitutively expressed perforin and granzyme B accumulated both in the epidermis and dermis.
Conversely, CD8+CD49a– Trm cells from psoriasis lesions predominantly generated IL-17 responses that promote local inflammation in this skin disease. Overall, CD49a expression delineates CD8+ Trm cell specialization in human epithelial barriers and correlates with the effector cell balance found in distinct inflammatory skin diseases.
| Language: | English |
|---|---|
| Publisher: | Cell Press |
| Year: | 2017 |
| Pages: | 287-300 |
| ISSN: | 10974180 and 10747613 |
| Types: | Journal article |
| DOI: | 10.1016/j.immuni.2017.01.009 |
| ORCIDs: | Folkersen, Lasse Westergaard |
CD49a CD8-Positive T-Lymphocytes Cell Separation Cytotoxicity, Immunologic Flow Cytometry Humans IL-15 Immunologic Memory Integrin alpha1 Lymphocyte Activation Microscopy, Confocal Psoriasis Skin T-Lymphocyte Subsets Vitiligo cytotoxicity granzyme B immunopathology perforin psoriasis tissue resident T cells vitiligo
