Journal article ยท Conference paper
Persistent developmental toxicity in rat offspring after low dose exposure to a mixture of endocrine disrupting pesticides
There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz, tebuconazole and procymidone, were examined.
Pregnant and lactating rat dams were dosed with a mixture of the five pesticides at three different doses, or with the individual pesticides at one of two doses.Adverse effects were observed in young and adult male offspring from the group exposed to the highest dose of the mixture. These included reduced prostate and epididymis weights, increased testes weights, altered prostate histopathology, increased density of mammary glands, reduced sperm counts, and decreased spatial learning.
As no significant effects were seen following single compound exposure at the doses included in the highest mixture dose, these results indicate cumulative adverse effects of the pesticide mixture.
Language: | English |
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Year: | 2012 |
Pages: | 237-250 |
Proceedings: | 40th European Teratology Society Conference |
ISSN: | 18731708 and 08906238 |
Types: | Journal article and Conference paper |
DOI: | 10.1016/j.reprotox.2012.05.099 |
ORCIDs: | Petersen, Marta Axelstad , Boberg, Julie , Christiansen, Sofie , Mandrup, Karen Riiber , Vinggaard, Anne Marie and Hass, Ulla |
Antiandrogen Behavior Developmental toxicology Endocrine disrupter Estrous Estrus Female Wistar rat Male Wistar rat Mammary gland Mixture Pesticides Reproductive organs Sperm count Steroid hormones Thyroidea Whole mount
Animals Behavior, Animal Bridged Bicyclo Compounds Drug Interactions Endocrine Disruptors Epoxy Compounds Female Genitalia, Male Imidazoles Learning Male Mammary Glands, Animal Maneb Memory Organ Size Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Sperm Count Triazoles Zineb epoxiconazole mancozeb prochloraz procymidone tebuconazole