Journal article
Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism
To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause. Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention.
Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR).
Insulin signaling was investigated in muscle biopsies. Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P
| Language: | English |
|---|---|
| Year: | 2018 |
| Pages: | 165-175 |
| ISSN: | 15300374 and 10723714 |
| Types: | Journal article |
| DOI: | 10.1097/GME.0000000000000981 |
| ORCIDs: | 0000-0003-4353-0362 , 0000-0002-3937-4697 , 0000-0002-2706-5547 , 0000-0002-8857-8100 , 0000-0001-8185-3408 , 0000-0002-2435-9558 , 0000-0003-3117-0451 and Christensen, Anders Nymark |
Glucose disposal Insulin sensitivity Insulin signaling Journal Article Menopause Physical activity
AKT2 protein, human Absorptiometry, Photon Adiposity Female Glucose Glycogen Synthase Hexokinase Humans Insulin Resistance Magnetic Resonance Imaging Middle Aged Physical Conditioning, Human Positron Emission Tomography Computed Tomography Postmenopause Premenopause Proto-Oncogene Proteins c-akt Quadriceps Muscle
