Journal article
Effects of 14-day oral low dose selenium nanoparticles and selenite in rat—as determined by metabolite pattern determination
National Food Institute, Technical University of Denmark1
Research group for Nano-Bio Science, National Food Institute, Technical University of Denmark2
Research Group for Risk Benefit, National Food Institute, Technical University of Denmark3
DHI Water - Environment - Health4
Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark5
Selenium (Se) is an essential element with a small difference between physiological and toxic doses. To provide more effective and safe Se dosing regimens, as compared to dosing with ionic selenium, nanoparticle formulations have been developed. However, due to the nano-formulation, unexpected toxic effects may occur.
We used metabolite pattern determination in urine to investigate biological and/or toxic effects in rats administered nanoparticles and for comparison included ionic selenium at an equimolar dose in the form of sodium selenite. Low doses of 10 and 100 fold the recommended human high level were employed to study the effects at borderline toxicity.
Evaluations of all significantly changed putative metabolites, showed that Se nanoparticles and sodium selenite induced similar dose dependent changes of the metabolite pattern. Putative identified metabolites included increased decenedioic acid and hydroxydecanedioic acid for both Se formulations whereas dipeptides were only increased for selenite.
These effects could reflect altered fatty acid and protein metabolism, respectively.
| Language: | English |
|---|---|
| Publisher: | PeerJ Inc. |
| Year: | 2016 |
| Pages: | e2601 |
| ISSN: | 21678359 |
| Types: | Journal article |
| DOI: | 10.7717/peerj.2601 |
| ORCIDs: | Hadrup, Niels , Löschner, Katrin , Ravn-Haren, Gitte and Frandsen, Henrik Lauritz |
Food Science and Technology Metabolic Sciences Metabolomic pattern recognition Nanoparticle Pharmacology Selenium Toxicology
