Journal article
Reflections on the aerobic fermentation stoichiometry of crabtree positive yeasts : Reflections on the Aerobic Fermentation Stoichiometry
Department of Chemical and Biochemical Engineering, Technical University of Denmark1
CHEC Research Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
Computer Aided Process Engineering Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark3
In this communication a stoichiometric steady state model for Crabtree positive yeasts is proposed. The model is sufficiently simple to be corroborated by experimental data on the key metabolic events around Dcrit. The key feature of the model is that the bottleneck aperture for biomass production in the model of Sonnleitner and Käppeli, 1986 shrinks abruptly at Dcrit and continues to decrease with increasing dilution rate.
A black box stoichiometric analysis of experiments reported in literature indicates that production of acetaldehyde might account for the abrupt shrinkage through a severe poisoning effect on the respiratory system.
Language: | English |
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Year: | 2014 |
Pages: | 632-637 |
ISSN: | 10970290 and 00063592 |
Types: | Journal article |
DOI: | 10.1002/bit.25110 |
ORCIDs: | Villadsen, John and Jørgensen, Sten Bay |