Journal article
Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity
Department of Chemistry, Technical University of Denmark1
Organic Chemistry, Department of Chemistry, Technical University of Denmark2
Department of Micro- and Nanotechnology, Technical University of Denmark3
Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark4
Center for Nanomedicine and Theranostics, Centers, Technical University of Denmark5
Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A2 towards various succinate-phospholipid conjugates has been investigated. The synthesis of six novel phospholipids is described, including two TOS phospholipids conjugates.
The studies revealed that the TOS conjugates are poor substrates for the enzyme whereas the phospholipids with alkyl and phenyl succinate moieties were hydrolyzed by the enzyme to a high extent.
| Language: | English |
|---|---|
| Year: | 2012 |
| Pages: | 3972-3978 |
| ISSN: | 14643391 and 09680896 |
| Types: | Journal article |
| DOI: | 10.1016/j.bmc.2012.05.024 |
| ORCIDs: | Melander, Fredrik , Andresen, Thomas Lars , Madsen, Robert and Clausen, Mads Hartvig |
