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Journal article

Production of the Auger emitter Sb-119 for targeted radionuclide therapy using a small PET-cyclotron

By Thisgaard, Helge1,2,3; Jensen, Mikael1,2,3

From

Biomedical Tracers, Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark1

Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark2

Risø National Laboratory for Sustainable Energy, Technical University of Denmark3

The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron.

With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.

Language: English
Year: 2009
Pages: 34-38
ISSN: 18729800 and 09698043
Types: Journal article
DOI: 10.1016/j.apradiso.2008.09.003
ORCIDs: Jensen, Mikael
Keywords

Biomedical tracers Biomedicinske sporstoffer Nuclear technologies Nukleare teknologier

Other keywords

Antimony Auger electrons Cancer Cyclotrons Excitation function Neoplasms Nuclear reaction Radiochemical separation Radioisotopes Radionuclide therapy Sb-119 Tomography, Emission-Computed

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