Journal article
Development of electrosprayed mucoadhesive chitosan microparticles
National Food Institute, Technical University of Denmark1
Research group for Nano-Bio Science, National Food Institute, Technical University of Denmark2
University of Münster3
Department of Micro- and Nanotechnology, Technical University of Denmark4
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark5
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark6
The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed.
In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering.
The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.
| Language: | English |
|---|---|
| Year: | 2018 |
| Pages: | 240-247 |
| ISSN: | 18791344 and 01448617 |
| Types: | Journal article |
| DOI: | 10.1016/j.carbpol.2018.02.062 |
| ORCIDs: | Mendes, Ana C. , Stephansen, Karen , Boisen, Anja , Nielsen, Line Hagner , Chronakis, Ioannis S. , 0000-0002-8530-1042 and 0000-0001-7949-5429 |
