Journal article
In vivo comparison of three ultrasound vector velocity techniques to MR phase contrast angiography
Department of Electrical Engineering, Technical University of Denmark1
Technical University of Denmark2
Copenhagen University Hospital Herlev and Gentofte3
Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark4
Center for Fast Ultrasound Imaging, Centers, Technical University of Denmark5
The objective of this paper is to validate angle independent vector velocity methods for blood velocity estimation. Conventional Doppler ultrasound (US) only estimates the blood velocity along the US beam direction where the estimate is angle corrected assuming laminar flow parallel to vessel boundaries.
This results in incorrect blood velocity estimates, when angle of insonation approaches 90° or when blood flow is non-laminar. Three angle independent vector velocity methods are evaluated in this paper: directional beamforming (DB), synthetic aperture flow imaging (STA) and transverse oscillation (TO).
The performances of the three methods were investigated by measuring the stroke volume in the right common carotid artery of 11 healthy volunteers with magnetic resonance phase contrast angiography (MRA) as reference. The correlation with confidence intervals (CI) between the three vector velocity methods and MRA were: DB vs.
MRA: R = 0.84 (p <0.01, 95% CI: 0.49–0.96); STA vs. MRA: R = 0.71 (p <0.05, 95% CI: 0.19–0.92) and TO vs. MRA: R = 0.91 (p <0.01, 95% CI: 0.69–0.98). No significant differences were observed for any of the three comparisons (DB vs. MRA: p = 0.65; STA vs. MRA: p = 0.24; TO vs. MRA: p = 0.36). Bland–Altman plots were additionally constructed, and mean differences with limits of agreements (LoA) for the three comparisons were: DB vs.
MRA = 0.17 ml (95% CI: −0.61–0.95) with LoA = −2.11–2.44 ml; STA vs. MRA = −0.55 ml (95% CI: −1.54–0.43) with LoA = −3.42–2.32 ml; TO vs. MRA = 0.24 ml (95% CI: −0.32–0.81) with LoA = −1.41–1.90 ml. According to the results, reliable volume flow estimates can be obtained with all three methods. The three US vector velocity techniques can yield quantitative insight into flow dynamics and visualize complex flow patterns, which potentially can give the clinician a novel tool for cardiovascular disease assessment.
Language: | English |
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Year: | 2009 |
Pages: | 659-667 |
ISSN: | 18749968 and 0041624x |
Types: | Journal article |
DOI: | 10.1016/j.ultras.2009.04.002 |
ORCIDs: | Jensen, Jørgen Arendt |
Blood flow Directional beamformin MR phase contrast angiography SDG 3 - Good Health and Well-being Synthetic aperture flow imaging Transverse oscillation Vector estimation
Algorithms Blood Flow Velocity Carotid Artery, Common Cerebral Angiography Cerebrovascular Circulation Directional beamforming Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Angiography Male Reproducibility of Results Sensitivity and Specificity Ultrasonography, Doppler Young Adult