Journal article
Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice
Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with a similar genetic background can be distinguished by their differing rates of the metabolism of 13C labeled glucose tracers, which can be imaged without hyperpolarization by using newly developed techniques for noise suppression.
Using this method, cancer subtypes that appeared to have similar metabolic profiles based on steady state metabolic measurement can be distinguished from each other. The metabolic maps from 13C-glucose imaging localized lactate production and overall glucose metabolism to different regions of some tumors.
Such tumor heterogeneity would not be not detectable in FDG-PET.
Language: | English |
---|---|
Publisher: | eLife Sciences Publications, Ltd |
Year: | 2019 |
ISSN: | 2050084x |
Types: | Journal article |
DOI: | 10.7554/eLife.46312 |
ORCIDs: | 0000-0002-2496-5283 , 0000-0001-7487-6169 , 0000-0002-7216-7788 and Ardenkjaer-Larsen, Jan Henrik |
Cancer biology Imaging MRI Magnetic resonance spectroscopy Metabolism Metabolomics Mouse SDG 3 - Good Health and Well-being Tumor microenvironment
Adenocarcinoma Animals Biology (General) Carbon Isotopes Carcinoma, Pancreatic Ductal Disease Models, Animal Glucose Magnetic Resonance Imaging Medicine Mice Pancreatic Neoplasms Q QH301-705.5 R Science cancer biology imaging magnetic resonance spectroscopy metabolism metabolomics mouse tumor microenvironment