Journal article · Conference paper
Elucidation of the biosynthesis of meroterpenoid yanuthone D in Aspergillus Niger
Department of Systems Biology, Technical University of Denmark1
Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark2
Department of Chemistry, Technical University of Denmark3
Organic Chemistry, Department of Chemistry, Technical University of Denmark4
We have elucidated the mode of biosynthesis of the meroterpenoid compound Yanuthone D in Aspergillus niger. We have successfully deleted all cluster genes, and identified a number of intermediates. Structures of the intermediates were solved using a combined approach comprising classical 1D- and 2D-NMR and tandem mass spectrometry (MS/MS).
In this study we have confirmed that Yanuthone D is of meroterpenoid origin, and we have identified an unexpected precursor, which has not before been reported for Aspergillus niger.
| Language: | English |
|---|---|
| Year: | 2012 |
| Pages: | 1069-1069 |
| Proceedings: | International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF |
| ISSN: | 14390221 and 00320943 |
| Types: | Journal article and Conference paper |
| DOI: | 10.1055/s-0032-1320343 |
| ORCIDs: | Klitgaard, Andreas , Jarczynska, Zofia Dorota , Larsen, Thomas Ostenfeld and Mortensen, Uffe Hasbro |
