Journal article
Oxidative Modification of Tryptophan-Containing Peptides
We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclodehydration between the peptide backbone and the indole side chain of tryptophan to form a fully conjugated indolyl-oxazole moiety.
The modified peptides show a characteristic and significant emission maximum at 425 nm, thus making the method a useful strategy for fluorescence labeling.
Language: | English |
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Publisher: | American Chemical Society |
Year: | 2018 |
Pages: | 344-349 |
ISSN: | 21568944 and 21568952 |
Types: | Journal article |
DOI: | 10.1021/acscombsci.8b00014 |
ORCIDs: | Qvortrup, Katrine |