Journal article · Conference paper
Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention
Based on the abundance of specific bacterial genera, the human gut microbiota can be divided into two relatively stable groups that might play a role in personalized nutrition. We studied these simplified enterotypes as prognostic markers for successful body fat loss on two different diets. A total of 62 participants with increased waist circumference were randomly assigned to receive an ad libitum New Nordic Diet (NND) high in fiber/wholegrain or an Average Danish Diet (ADD) for 26 weeks.
Participants were grouped into two discrete enterotypes by their relative abundance of Prevotella spp. divided by Bacteroides spp. (P/B ratio) obtained by quantitative PCR analysis. Modifications of dietary effects of pre-treatment P/B group were examined by linear mixed models. Among individuals with high P/B the NND resulted in a 3.15 kg (95%CI 1.55;4.76, P<0.001) larger body fat loss compared to ADD whereas no differences was observed among individuals with low P/B (0.88 kg [95% CI −0.61;2.37, P=0.25]).
Consequently, a 2.27 kg (95%CI 0.09;4.45, P=0.041) difference in responsiveness to the diets were found between the two groups. In summary, subjects with high P/B-ratio appeared more susceptible to lose body fat on diets high in fiber and wholegrain than subjects with a low P/B-ratio.
Language: | English |
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Publisher: | Nature Publishing Group |
Year: | 2017 |
Pages: | 580-583 |
ISSN: | 14765497 and 03070565 |
Types: | Journal article and Conference paper |
DOI: | 10.1038/ijo.2017.220 |
ORCIDs: | Roager, Henrik Munch , Licht, Tine Rask , Bahl, Martin Iain , 0000-0001-9440-2737 , 0000-0001-7621-3131 , 0000-0003-4897-3955 and 0000-0001-8968-8996 |