Journal article
Network Medicine Strikes a Blow against Breast Cancer
Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
Language: | English |
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Year: | 2012 |
Pages: | 731-733 |
ISSN: | 10974172 and 00928674 |
Types: | Journal article |
DOI: | 10.1016/j.cell.2012.04.014 |
ORCIDs: | 0000-0001-8675-6527 |