Journal article
Preparation of CLA ascorbyl ester with improved volumetric productivity by an ionic liquid-based reaction system
A new approach to the enzymatic production Of conjugated linoleic acid (CLA) ascorbyl ester with a remarkably high volumetric productivity (120-200 g L-1) has been developed, in which strong solvation by tOMA-TFA (methyltrioctylammonium trifluoroacetate) enables a high concentration of ascorbic acid to be applied, and in which t-butanol enhances conversion by changing the equilibrium constant of the activity coefficients.
This work has experimentally demonstrated the practicability of achieving efficient reactions of polar compounds at high concentrations in ionic liquids without significant loss of enzyme activity.
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2008 |
Pages: | 3196-3201 |
ISSN: | 14770539 and 14770520 |
Types: | Journal article |
DOI: | 10.1039/b807710j |
1-butyl-3-methylimidazolium Ascorbic Acid Bioreactors Candida Chromatography, High Pressure Liquid Enzymes, Immobilized Esterification Esters Fungal Proteins Imidazoles Ionic Liquids Linoleic Acids, Conjugated Lipase Novozyme 435 Quaternary Ammonium Compounds Temperature Thermodynamics Trifluoroacetic Acid tert-Butyl Alcohol trioctylmethylammonium