Journal article
Mathematical Beta Cell Model for Insulin Secretion following IVGTT and OGTT
Evaluation of beta cell function is conducted by a variety of glucose tolerance tests and evaluated by a number of different models with less than perfect consistency among results obtained from different tests. We formulated a new approximation of the distributed threshold model for insulin secretion in order to approach a model for quantifying beta cell function, not only for one, but for several different experiments.
Data was obtained from 40 subjects that had both an oral glucose tolerance test (OGTT) and an intravenous tolerance test (IVGTT) performed. Parameter estimates from the two experimental protocols demonstrate similarity, reproducibility, and indications of prognostic relevance. Useful first phase indexes comprise the steady state amount of ready releasable insulin A and the rate of redistribution k , where both yield a considerable correlation (both r=0.67) between IVGTT and OGTT estimates.
For the IVGTT, A correlates well ( r=0.96) with the 10 min area under the curve of insulin above baseline, whereas k represents a new and possibly more fundamental first phase index. For the useful second phase index , a correlation of 0.75 was found between IVGTT and OGTT estimates.
Language: | English |
---|---|
Publisher: | Kluwer Academic Publishers-Plenum Publishers |
Year: | 2006 |
Pages: | 1343-1354 |
Journal subtitle: | Journal of the Biomedical Engineering Society |
ISSN: | 15739686 , 00906964 and 15216047 |
Types: | Journal article |
DOI: | 10.1007/s10439-006-9154-0 |
ORCIDs: | Madsen, Henrik |
Adult Biochemistry, general Biomedical Engineering Biomedicine Biomedicine general Biophysics/Biomedical Physics Computer Simulation Diagnosis, Computer-Assisted Female Glucose Glucose Tolerance Test Humans Insulin Insulin-Secreting Cells Male Mechanics Metabolic Clearance Rate Mixed-effects Models, Biological Pancreatic beta cell Parameter estimation Physiological models Prediabetic State Reproducibility of Results Sensitivity and Specificity