Journal article
Modeling of glutamate-induced dynamical patterns
Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity.
We identify by chaos analysis a surprising possibility that muscarinergic receptors can help the system out of a chaotic regime.
Language: | English |
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Year: | 2009 |
Pages: | 395-407 |
ISSN: | 17936462 and 01290657 |
Types: | Journal article |
DOI: | 10.1142/S0129065709002105 |
Action Potentials Animals Computer Simulation Epilepsy, Temporal Lobe Extracellular Space Glutamate Plasma Membrane Transport Proteins Glutamic Acid Hippocampus Humans Mathematical Concepts Neural Pathways Nonlinear Dynamics Pyramidal Cells Rats Receptors, N-Methyl-D-Aspartate Synapses Synaptic Transmission