Journal article
Production of glycidyl ethers by chemo-enzymatic epoxidation of allyl ethers
Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden1
Perstorp Specialty Chemicals AB, R&D, SE-284 80 Perstorp, Sweden2
Production of glycidyl ethers is industrially carried out by reacting alcohols with epichlorhydrin, a potentially carcinogenic compound. This paper investigates a less hazardous alternative—that of a chemo-enzymatic process in which Candida antarctica lipase B catalysed generation of peracid from a carboxylic acid is followed by a Prileshajev epoxidation of the corresponding allyl ether.
Trimethylolpropane monoallyl ether (TMPME) was used as a model substrate. A maximal epoxide product yield of 77% was achieved through the optimization of temperature, acid concentration and hydrogen peroxide concentration. Peracid formation was considerably faster than the subsequent epoxidation step, and accumulation of the peracid was found to be important to drive the epoxidation forward.
Language: | English |
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Publisher: | Elsevier BV |
Year: | 2008 |
Pages: | 1-6 |
ISSN: | 18733158 and 13811177 |
Types: | Journal article |
DOI: | 10.1016/j.molcatb.2007.11.015 |