Journal article · Preprint article
The human cell atlas
Massachusetts Institute of Technology1
University of Pennsylvania2
Heidelberg University 3
Ludwig Maximilian University of Munich4
Takara Bio USA, Inc.5
University of Oxford6
Newcastle University7
Wellcome Sanger Institute8
Stanford University9
Oxford University Hospitals NHS Foundation Trust10
University of California at San Francisco11
University of Cambridge12
Allen Institute for Brain Science13
Karolinska Institutet14
KTH Royal Institute of Technology15
National Institute of Biomedical Genomics16
Icahn School of Medicine at Mount Sinai17
University of Cape Town18
University of Groningen19
Radboud University Nijmegen20
Memorial Sloan-Kettering Cancer Center21
Broad Institute of Harvard University and Massachusetts Institute of Technology22
Harvard University23
University of Edinburgh24
New York University25
Netherlands Cancer Institute26
University of Texas MD Anderson Cancer Center27
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark28
High Throughput Molecular Bioscience, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark29
Human Cell Atlas Meeting Participants30
Weizmann Institute of Science31
European Molecular Biology Laboratory32
University of Zurich33
RIKEN34
Utrecht University35
Swiss Federal Institute of Technology Lausanne36
...and 26 moreThe recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology).
An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.
Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
| Language: | English |
|---|---|
| Publisher: | eLife Sciences Publications, Ltd |
| Year: | 2017 |
| ISSN: | 2050084x |
| Types: | Journal article and Preprint article |
| DOI: | 10.7554/eLife.27041 |
| ORCIDs: | 0000-0003-3293-3158 , 0000-0001-7202-7243 , 0000-0001-9935-843X , 0000-0002-4056-0550 , 0000-0001-6302-5705 , 0000-0002-3927-2084 , 0000-0001-9012-6552 , 0000-0003-0202-7816 , 0000-0001-8926-8836 , 0000-0001-9448-8833 , 0000-0001-9151-5154 , 0000-0003-2445-670X and 0000-0001-9004-1225 |
