Journal article
Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary
Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail1
German Environment Agency2
National Food Institute, Technical University of Denmark3
Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark4
National Institutes of Health5
The Danish Environmental Protection Agency6
European Commission Joint Research Centre Institute7
Charité – Universitätsmedizin Berlin8
A workshop was held in Berlin September 12–14th 2012 to assess the state of the science of the data supporting low dose effects and non-monotonic dose responses (“low dose hypothesis”) for chemicals with endocrine activity (endocrine disrupting chemicals or EDCs). This workshop consisted of lectures to present the current state of the science of EDC action and also the risk assessment process.
These lectures were followed by breakout sessions to integrate scientists from various backgrounds to discuss in an open and unbiased manner the data supporting the “low dose hypothesis”. While no consensus was reached the robust discussions were helpful to inform both basic scientists and risk assessors on all the issues.
There were a number of important ideas developed to help continue the discussion and improve communication over the next few years.
| Language: | English |
|---|---|
| Year: | 2013 |
| Pages: | 847-856 |
| ISSN: | 18791298 and 00456535 |
| Types: | Journal article |
| DOI: | 10.1016/j.chemosphere.2013.06.043 |
| ORCIDs: | Hass, Ulla |
ANSES BPA BfR Bundesinstitut für Risikobewertung, German Federal Institute for Risk Assessment Consensus Development Conferences as Topic Dose-Response Relationship, Drug EAC EDC EFSA EPA Endocrine Disruptors Environmental Pollutants European Food Safety Authority FDA French Agency for Food, Environmental and Occupational Health & Safety GLP Good Laboratory Practices Humans NGO NIEHS NMDR NMDRC NOAEL NTP National Institutes of Environmental Health Sciences OECD Organization for Economic Cooperation and Development Risk Assessment US Environmental Protection Agency US Food and Drug Administration US National Toxicology Program bisphenol A endocrine active compound endocrine disrupting chemical no observed adverse effect level non-governmental organization non-monotonic dose response non-monotonic dose response curve
