Journal article
Campylobacter jejuni strains of human and chicken origin are invasive in chickens after oral challenge
Technical University of Denmark1
Section of Poultry Diseases, Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark2
Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark3
National Veterinary Institute, Technical University of Denmark4
Section for Veterinary Diagnostics, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark5
Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark6
The aim of the study was to evaluate the colonizing ability and the invasive capacity of selected Campylobacter jejuni strains of importance for the epidemiology of C jejuni in Danish broiler chickens. Four C jejuni strains were selected for experimental colonization Studies in day-old and 14-day-old chickens hatched from specific pathogen free (SPF) eggs.
Of the four C jejuni strains tested, three were Penner heat-stable serotype 2,flaA type 1/1, the most common type found among broilers and human cases in Denmark. The fourth strain was Penner heat-stable serotype 19, which has been shown to be associated with the Guillain Barre Syndrome (GBS) in humans.
The minimum dose for establishing colonization in the clay-old chickens was approximately 2 cfu, whereas two- to threefold higher doses were required for establishing colonization in the 14-day-old chickens. Two of the C jejuni strains were shown to be invasive in orally challenged chickens as well as in three different human epithelial cell lines.
Language: | English |
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Publisher: | American Association of Avian Pathologists, Inc. |
Year: | 2006 |
Pages: | 10-14 |
ISSN: | 19384351 and 00052086 |
Types: | Journal article |
DOI: | 10.1637/7376-051005R.1 |
ORCIDs: | Bang, Dang Duong and Andresen, Lars Ole |