Journal article
Locked and Unlocked Nucleosides in Functional Nucleic Acids
In
Molecules
—
2011, Volume 16, Issue 6, pp. 4511-4526
From
Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M 5230, Denmark; E-Mail:
Abstract
Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
| Language: | Undetermined |
|---|---|
| Publisher: | MDPI |
| Year: | 2011 |
| Pages: | 4511-4526 |
| ISSN: | 14203049 |
| Types: | Journal article |
| DOI: | 10.3390/molecules16064511 |
