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Journal article

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

By Kato, Hikaru1; Sebe, Momona1; Nagaki, Mika1; Eguchi, Keisuke1; Kagiyama, Ippei1; Hitora, Yuki1; Frisvad, Jens Christian2,3,4,5; Williams, Robert M.6; Tsukamoto, Sachiko1

From

Kumamoto University1

Department of Biotechnology and Biomedicine, Technical University of Denmark2

Section for Synthetic Biology, Department of Biotechnology and Biomedicine, Technical University of Denmark3

Fungal Chemodiversity, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark4

Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark5

University of Colorado6

Four new norditerpenes, taichunins A-D ( 1-4 ), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

Language: English
Publisher: American Chemical Society and American Society of Pharmacognosy
Year: 2019
Pages: 1377-1381
ISSN: 15206025 and 01633864
Types: Journal article
DOI: 10.1021/acs.jnatprod.8b01032
ORCIDs: Frisvad, Jens Christian , 0000-0001-9551-831X , 0000-0003-4271-2543 and 0000-0002-7993-381X
Keywords

Anti-Infective Agents Antibiotics, Antineoplastic Anticholesteremic Agents Aspergillus Diterpenes HeLa Cells Humans Magnetic Resonance Spectroscopy Molecular Structure Osteoclasts Proteasome Endopeptidase Complex RANK Ligand TNFSF11 protein, human

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