Conference paper
Impact Of Mutation-derived Antigens In Immune Recognition Of Hematological Malignancies, Specifically Myeloid Dysplastic Syndromes (MDS)
National Veterinary Institute, Technical University of Denmark1
Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark2
Technical University of Denmark3
Department of Systems Biology, Technical University of Denmark4
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark5
Cancer Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark6
Georg-Speyer-Haus7
Mutation-derived neoepitopes have been suggested as a major component for immune recognition of solid tumors with a high mutational load, e.g. Melanoma and Non-Small-Cell Lung Cancer (NSCLC). Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by increasing bone marrow failure due to clonal expansion of immature dysplastic cells in the bone marrow.
Compared to Melanoma and NSCLC, these dysplastic cells carry low numbers of point mutations, but high levels of frameshifts, indels, splice variations or epigenetic changes. All of which may contribute to the generation of tumor-specific neoepitopes.
| Language: | English |
|---|---|
| Year: | 2016 |
| Pages: | 66-66 |
| Proceedings: | 21st Congress of the European Hematology Association |
| ISSN: | 15928721 and 03906078 |
| Types: | Conference paper |
| ORCIDs: | Saini, Sunil Kumar , Bentzen, Amalie Kai , Eklund, Aron Charles and Hadrup, Sine Reker |
