Journal article
EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging
Parameters of relevance to oximetry with Overhauser magnetic resonance imaging (OMRI) have been measured for three single electron contrast agents of the triphenylmethyl type. The single electron contrast agents are stable and water soluble. Magnetic resonance properties of the agents have been examined with electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and dynamic nuclear polarization (DNP) at 9.5 mT in water, isotonic saline, plasma, and blood at 23 and 37°C.
The relaxivities of the agents are about 0.2–0.4 mM−1s−1and the DNP enhancements extrapolate close to the dipolar limit. The agents have a single, narrow EPR line, which is analyzed as a Voigt function. The linewidth is measured as a function of the agent concentration and the oxygen concentration. The concentration broadenings are about 1–3 μT/mM and the Lorentzian linewidths at infinite dilution are less than 1 μT in water at room temperature.
The longitudinal electron spin relaxation rate is calculated from the DNP enhancement curves. The oxygen broadening in water is about 50 μT/mM O2at 37°C. These agents have good properties for oximetry with OMRI.
Language: | English |
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Year: | 1998 |
Pages: | 1-12 |
ISSN: | 10960856 and 10907807 |
Types: | Journal article |
DOI: | 10.1006/jmre.1998.1438 |
ORCIDs: | Ardenkjær-Larsen, J. H. |
Algorithms Chemical Phenomena Chemistry, Physical Contrast Media Electron Spin Resonance Spectroscopy Electrons Humans Image Enhancement Isotonic Solutions Linear Models Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Models, Chemical Oximetry Oxygen Plasma Sodium Chloride Solubility Temperature Trityl Compounds Water