Journal article
Substitution of Fish for Red Meat or Poultry and Risk of Ischemic Stroke
We investigated the risk of ischemic stroke and its subtypes when red meat or poultry was substituted with fish. A total of 57,053 participants aged 50⁻65 years at baseline were included in the Danish Diet, Cancer and Health study. All participants filled in a food-frequency questionnaire at recruitment.
Potential ischemic stroke cases were identified by linkage to the Danish National Patient Register, and all cases were validated and subclassified. Substitutions were investigated as 150 g/week of fish for 150 g/week of red meat or of poultry using multivariable Cox proportional hazard regression models.
During 13.5 years of follow-up, 1879 participants developed an ischemic stroke. Replacing red meat or poultry with fish was not associated with the rate of total ischemic stroke, but there was a statistically significant lower rate of large artery atherosclerosis when fish replaced processed (hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.67; 0.90) and unprocessed (HR: 0.87; 95% CI: 0.75; 0.99) red meat.
A statistically significant higher rate of cardioembolism was found when poultry was replaced by total fish (HR: 1.42; 95% CI: 1.04; 1.93). When fatty fish replaced unprocessed red meat, a statistically significant lower rate of small-vessel occlusion was found (HR: 0.88; 95% CI: 0.77; 0.99). In conclusion, replacing red meat with fish was not associated with risk of total ischemic stroke but was associated with a lower risk of subtypes of ischemic stroke.
Language: | English |
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Publisher: | MDPI |
Year: | 2018 |
Pages: | 1648 |
ISSN: | 20726643 |
Types: | Journal article |
DOI: | 10.3390/nu10111648 |
ORCIDs: | Jakobsen, Marianne Uhre , 0000-0002-9420-2783 , 0000-0002-2518-9335 , 0000-0003-0252-8039 , 0000-0003-4385-2097 and 0000-0001-6429-7921 |
SDG 3 - Good Health and Well-being TOAST classification cohort studies diet fish ischemic stroke meat poultry substitution models
Aged Animals Anthropometry Brain Ischemia Cohort studies Denmark Diet Exercise Female Fish Fishes Follow-Up Studies Humans Ischemic stroke Life Style Male Meat Middle Aged Nutrition. Foods and food supply Poultry Proportional Hazards Models Red Meat Risk Factors Seafood Stroke Substitution models Surveys and Questionnaires TX341-641