Conference paper
High-throughput automated system for statistical biosensing employing microcantilever arrays
In this paper we present a completely new and fully automated system for parallel microcantilever-based biosensing. Our platform is able to monitor simultaneously the change of resonance frequency (dynamic mode), of deflection (static mode), and of surface roughness of hundreds of cantilevers in a very short time over multiple biochemical reactions.
We have proven that our system is capable to measure 900 independent microsensors in less than a second. Here, we report statistical biosensing results performed over a haptens-antibody assay, where complete characterization of the biochemical binding on the cantilever surfaces is obtained with higher accuracy than standard optical lever-based setups.
Language: | English |
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Year: | 2011 |
Pages: | 877-880 |
Proceedings: | 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS) |
ISBN: | 1424496322 , 1424496349 , 9781424496327 and 9781424496341 |
ISSN: | 10846999 |
Types: | Conference paper |
DOI: | 10.1109/MEMSYS.2011.5734565 |
Laser beams Measurement by laser beam Optical sensors Resonant frequency Surface roughness Surface treatment biochemical binding biochemical reactions biochemistry biosensors bonds (chemical) cantilever surfaces cantilevers dynamic mode haptens-antibody assay high-throughput automated system microcantilever arrays microsensors molecular biophysics optical lever-based setups readout electronics resonance frequency static mode statistical biosensing surface roughness