Book chapter
Statistical Shape Clustering of Left Atrial Appendages
Fifteen percent of all strokes are caused by emboli formed in the left atrium (LA) in case of atrial fibrillation (AF). The most common site of thrombus formation is inside the left atrial appendage (LAA). The LAA is accounting for 70% to 90% of the thrombi formed in the LA in patients with non-valvular AF.
Studies have shown there is a correlation between the LAA morphology and risk of ischemic stroke; Chicken Wing and Cauliflower LAA shapes are associated with lower and higher risk, respectively. These two LAA shape categories come from a popular classification in the medical domain, but it is subjective and based on qualitative shape parameters.
In this paper, we describe a full framework for shape analysis and clustering of the LAA. Initially, we build a point distribution model to quantitatively describe the LAA shape variation based on 103 LAA surfaces segmented and reconstructed from multidetector computed tomography volumes. We are successfully able to determine point correspondence between LAA surfaces, by non-rigid volumetric registration of signed distance fields.
To validate if LAA shapes are clustered, we employ an unsupervised clustering on the shape models parameters to estimate the natural number of clusters in our training set, where the number of shape clusters is estimated by validating the test log-likelihood of several Gaussian mixture models using two level crossvalidation.
We found that the LAAs surfaces basically formed two shape clusters broadly corresponding to the Chicken wing and non-Chicken Wing morphologies, which fits well with clinical knowledge.
Language: | English |
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Publisher: | Springer |
Year: | 2019 |
Pages: | 32-39 |
Proceedings: | Statistical Atlases and Computational Modeling of the Heart workshop |
Series: | Lecture Notes in Computer Science |
Journal subtitle: | 9th International Workshop, Stacom 2018, Held in Conjunction With Miccai 2018, Granada, Spain, September 16, 2018, Revised Selected Papers |
ISBN: | 3030120287 , 3030120295 , 9783030120283 and 9783030120290 |
ISSN: | 03029743 |
Types: | Book chapter |
DOI: | 10.1007/978-3-030-12029-0_4 |
ORCIDs: | Slipsager, Jakob Mølkjær , Juhl, Kristine Aavild and Paulsen, Rasmus Reinhold |