Conference paper · Book chapter
BIOPRO-Sim: A benchmark simulation model for bio-manufacturing processes
Fondazione Politecnico di Milano1
PROSYS - Process and Systems Engineering Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
Department of Chemical and Biochemical Engineering, Technical University of Denmark3
KT Consortium, Department of Chemical and Biochemical Engineering, Technical University of Denmark4
In this work, an end to end bio-pharmaceutical production process of the API lovastatin is developed through a systematic process synthesis and design approach, and then simulated. The developed simulation is intended to be used as benchmark process model as it captures the generic process dynamics of a bio-pharmaceutical process, and as such it is well-suited to use as a test problem to evaluate different processing scenarios in continuous fermentation processes.
The synthesis and design of the simulation is realised through a methodology based on two complimentary steps, that can be applied individually or in conjunction, and is adopted to synthesize the upstream and downstream processing pathway. As such, the process model can be operated either as a whole, or as an individual upstream or downstream process.
The open loop response of the whole benchmark simulation is presented here.
| Language: | English |
|---|---|
| Publisher: | Elsevier |
| Year: | 2019 |
| Pages: | 961-966 |
| Proceedings: | 29th European Symposium on Computer Aided Process Engineering |
| Series: | Computer Aided Chemical Engineering |
| ISBN: | 0128186348 , 0128186356 , 9780128186343 and 9780128186350 |
| ISSN: | 15707946 |
| Types: | Conference paper and Book chapter |
| DOI: | 10.1016/B978-0-12-818634-3.50161-2 |
| ORCIDs: | A. Udugama, Isuru , Gernaey, Krist V. and Mansouri, Seyed Soheil |
