Book chapter · Conference paper
A generic process template for continuous pharmaceutical production
Department of Chemical and Biochemical Engineering, Technical University of Denmark1
Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
AstraZeneca3
Computer Aided Process Engineering Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark4
In the work reported here, a conceptual generic continuous process template for pharmaceutical production is presented. The template is demonstrated on a nitro reduction case study that should in principle be generic such that it can handle a series of substrates with similar molecular functionality.
To assist in adoption of different substrates, a systematic substrate adoption methodology (SAM) has also been developed. The objective of the generic process template together with the SAM is to provide flexibility as well as increased efficiency to continuous processes while reducing inventory for safer operations (from 50 to 100 L in batch or 3 to 5 L in continuous processes).
It is shown that the use of the template together with SAM can lead to potential savings in product development times through flexible and efficient production of Kg amounts of product material for clinical trials and other analyses.
| Language: | English |
|---|---|
| Publisher: | Elsevier |
| Year: | 2012 |
| Pages: | 715-719 |
| Proceedings: | 11th International Symposium on Process Systems Engineering |
| Series: | Computer Aided Chemical Engineering |
| ISBN: | 0444595058 , 0444595082 , 128354010X , 128354010x , 9780444595058 , 9780444595089 and 9781283540100 |
| ISSN: | 15707946 |
| Types: | Book chapter and Conference paper |
| DOI: | 10.1016/B978-0-444-59507-2.50135-9 |
| ORCIDs: | Gernaey, Krist and Woodley, John |
