Book chapter · Conference paper
Methodological Approach for Modeling of Multienzyme in-pot Processes
This paper presents a methodological approach for modeling multi-enzyme in-pot processes. The methodology is exemplified stepwise through the bi-enzymatic production of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). In this case study, sensitivity analysis is also used to evaluate the reliability of all parameters of the model suggested in literature [5], Results, from the sensitivity analysis, are used as criteria for a systematic simplification of the model structure.
Consequently, model complexity was reduced without compromising the general predictive performance. A deviation of less than 5% from the original model was found.
Language: | English |
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Publisher: | Elsevier |
Year: | 2011 |
Pages: | 1346-1350 |
Proceedings: | 21st European Symposium on Computer Aided Process Engineering |
Series: | Computer Aided Chemical Engineering |
ISBN: | 044453895X , 044453895x , 0444538968 , 128316440X , 128316440x , 9780444538956 , 9780444538963 and 9781283164405 |
ISSN: | 15707946 |
Types: | Book chapter and Conference paper |
DOI: | 10.1016/B978-0-444-54298-4.50048-9 |
ORCIDs: | Sin, Gürkan , Gernaey, Krist and Woodley, John |