Conference paper · Book chapter
Robust Market Launch Planning for a Multi- Echelon Pharmaceutical Supply Chain
Operations Management, Department of Management Engineering, Technical University of Denmark1
Department of Management Engineering, Technical University of Denmark2
Technical University of Munich3
Computer Aided Process Engineering Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark4
Department of Chemical and Biochemical Engineering, Technical University of Denmark5
It is well known, that the pharmaceutical industry is struggling with increasing cost and length of R&D projects. Earnings of a drug drop drastically after patent expiration. Thus, the industry spends much effort on reducing Time-to-Market. In the literature, little attention is given to drug launching activities after the drug has been approved.
In this paper, we present a recourse-based stochastic model, which allows for time phasing the market entries to balance the fluctuating demand with the fixed and periodic production of the active pharmaceutical ingredient. The two major risk elements during launch are forecasting inaccuracy and the risk of a required label change from local regulatory authorities.
Robust solutions are found by implementing the Robust Optimization framework.
| Language: | English |
|---|---|
| Publisher: | Elsevier |
| Year: | 2011 |
| Pages: | 935-939 |
| Proceedings: | 21st European Symposium on Computer Aided Process Engineering |
| Series: | Computer Aided Chemical Engineering |
| ISBN: | 044453895X , 044453895x , 0444538968 , 128316440X , 128316440x , 9780444538956 , 9780444538963 and 9781283164405 |
| ISSN: | 15707946 |
| Types: | Conference paper and Book chapter |
| DOI: | 10.1016/B978-0-444-53711-9.50187-5 |
