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Conference paper

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

By Hansen, Rie Beck1,2,3; Gordon, Jeremy W.4; Shin, Peter J.4; Zhu, Zihan5; Mammoli, Daniele4; Munster, Pamela N.4; Aggarwal, Rahul4; Ohliger, Michael A.4; Larson, Peder EZ4; Hanson, Lars G.1,2,3; Ardenkjær-Larsen, Jan Henrik1,2,3; Vigneron, Daniel B.4 ...and 2 more

From

Department of Electrical Engineering, Technical University of Denmark1

Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark2

Center for Hyperpolarization in Magnetic Resonance, Centers, Technical University of Denmark3

University of California at San Francisco4

University of California at Berkeley5

Hyperpolarized 13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human 13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation.

In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

Language: English
Year: 2018
Proceedings: Joint Annual Meeting ISMRM-ESMRMB 2018
Types: Conference paper
ORCIDs: Hansen, Rie Beck , Hanson, Lars G. and Ardenkjær-Larsen, Jan Henrik

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