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10 items by relevance
1 Journal article

In vivo toxicity of cationic micelles and liposomes

Knudsen, Kristina Bram; Northeved, Helle; Ek, Pramod Kumar; Permin, Anders; Gjetting, Torben; Andresen, Thomas Lars; et al. (7 more)

Nanomedicine: Nanotechnology, Biology and Medicine — 2015, Volume 11, Issue 2, pp. 467-477

This study investigated toxicity of nanocarriers comprised of cationic polymer and lipid components often used in gene and drug delivery, formulated as cationic micelles and liposomes. Rats were injected intravenously with 10, 25 or 100 mg/kg and sacrificed after 24 or 48 h, or 24 h after the last

Year: 2015

Language: English

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2 Journal article

Monocyte targeting and activation by cationic liposomes formulated with a TLR7 agonist

Johansen, Pia Thermann; Zucker, Daniel; Parhamifar, Ladan; Pourhassan, Houman; Madsen, Ditte Villum; Henriksen, Jonas Rosager; et al. (5 more)

Expert Opinion on Drug Delivery — 2015, Volume 12, Issue 7, pp. 1045-1058

expression.Results: The liposonnes target nnonocytes specifically over lymphocytes and granulocytes in human whole blood, and show association with 75 - 95% of the nnonocytes after 1 h incubation. Formulations of TMX-202 in cationic liposomes were potent in targeting and activation of monocytes, with strong

Year: 2015

Language: English

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3 Journal article

Mechanisms of Selective Monocyte Targeting by Liposomes Functionalized with a Cationic, Arginine-Rich Lipopeptide

Münter, Rasmus; Bak, Martin; Christensen, Esben; Kempen, Paul; Larsen, Jannik; Kristensen, Kasper; et al. (2 more)

Acta Biomaterialia — 2022, Volume 144, pp. 96-108

Stimulation of monocytes with immunomodulating agents can harness the immune system to treat a long range of diseases, including cancers, infections and autoimmune diseases. To this end we aimed to develop a monocyte-targeting delivery platform based on cationic liposomes, which can be utilized

Year: 2022

Language: English

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4 Ahead of Print article · Journal article

Deciphering the monocyte-targeting mechanisms of PEGylated cationic liposomes by investigating the biomolecular corona

Münter, Rasmus; Bak, Martin; Thomsen, Mikkel E; Parhamifar, Ladan; Stensballe, Allan; Simonsen, Jens B; et al. (2 more)

International Journal of Pharmaceutics — 2024, pp. 124129

Cationic liposomes specifically target monocytes in blood, rendering them promising drug-delivery tools for cancer immunotherapy, vaccines, and therapies for monocytic leukaemia. The mechanism behind this monocyte targeting ability is, however, not understood, but may involve plasma proteins

Year: 2024

Language: English

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5 Journal article

Whole blood targeting and activation of monocytes with TLR7 agonist formulated in cationic liposomes

Jensen, Simon S; Johansen, Pia T; Zucker, Daniel; Henriksen, Jonas; Andresen, Thomas; Barberis, Alcide; et al. (4 more)

Journal for Immunotherapy of Cancer — 2013, Volume 1, Issue Suppl 1, pp. P130-P130

Year: 2013

Language: English

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6 Conference paper

PEGylated cationic liposomal-oxaliplatin display impressive anticancer efficacy by dual-targeting of immunosuppressive populations and cancer-cells

Petersen, Lars; Ringgaard, Lars; Melander, Fredrik; Østrem, Ragnhild Garborg; Kristensen, Kasper; Henriksen, Jonas; et al. (3 more)

Journal for Immunotherapy of Cancer — 2019, Volume 7, Issue Suppl. 1

Year: 2019

Language: English

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7 Journal article

In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines

Roursgaard, Martin; Knudsen, Kristina Bram; Northeved, Helle; Persson, Mikael; Christensen, Tina; Ek, Pramod Kumar; et al. (7 more)

Toxicology in Vitro — 2016, Volume 36, pp. 164-171

The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. A screening battery was established for assessment of a broad range

Year: 2016

Language: English

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