Journal article
Genetic predisposition to acute lymphoblastic leukemia: Overview on behalf of the I-BFM ALL Host Genetic Variation Working Group
Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany. Electronic address: kratz.christian@mh-hannover.de.1
Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.2
Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, Département de Génétique, Paris, France; INSERM UMR 1131, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris-Sorbonne-Cité, Paris, France.3
Environmental causes of childhood acute lymphoblastic leukemia (ALL) remain largely undiscovered. In contrast, multiple germline ALL risk variants have been identified in the recent years. Apart from the low-risk common ALL risk alleles identified through genome wide association studies, rare germline mutations that cause cancer prone syndromes have been found to be associated with an increased risk of developing ALL.
Here, we review the germline genetic changes known to be associated with ALL.
| Language: | English |
|---|---|
| Year: | 2016 |
| Pages: | 111-115 |
| ISSN: | 18780849 and 17697212 |
| Types: | Journal article |
| DOI: | 10.1016/j.ejmg.2015.10.003 |
